Holders Arsenal will host record eight-time winners Lyon in the league phase of the revamped Women's Champions League.
Arsenal beat Barcelona in last season's final to win the Champions League for a second time, having previously lifted the trophy in 2007.
The Gunners will also welcome Real Madrid and Twente, with trips to Bayern Munich, Benfica and Belgian club Leuven to come.
Debutants Manchester United - who came through four rounds of qualifying to reach the main draw - can also prepare for a home meeting with Lyon, with Paris FC and Norwegian side Valerenga also set to visit.
Marc Skinner's side will travel to Wolfsburg, Juventus and Atletico Madrid.
Chelsea will have the chance for revenge when they reunite with Barcelona, having lost 8-2 on aggregate in last season's semi-finals.
Paris FC and Roma also head to Chelsea, with the Women's Super League champions travelling to Wolfsburg, St Polten and Twente.