The 197th Manchester derby takes place at Etihad Stadium on Sunday, but will it be the Blues or the Reds who claim the points - and local bragging rights?
"This is so hard to call, for many reasons," said BBC Sport football expert Chris Sutton.
"Manchester United could be buoyed by their win over Burnley before the international break, but I actually have bigger doubts about what we will see from Manchester City after seeing them capitulate the way they did against Brighton."
Sutton is making predictions for all 380 Premier League games this season, against AI, BBC Sport readers and a variety of guests.
For week four, he takes on Only The Poets frontman Tommy Longhurst.
The Reading band are charging £1 a ticket when they play the O2 Academy Brixton, in February 2026. The gig takes place a few days after the release of their debut album, And I'd Do It Again.
Do you agree with their scores? You can make your own predictions below.
The most popular scoreline selected for each game is used in the scoreboards and tables at the bottom of this page.
A correct result (picking a win, draw or defeat) is worth 10 points. The exact score earns 40 points.